Southeast Missouri State University is a public university located in Cape Girardeau, Missouri, USA. Established in 1873, it offers undergraduate and postgraduate programmes in business, computer science, cybersecurity, engineering technology, education, health sciences, agriculture and the arts.

The university focuses on career-oriented education, practical learning and student support. It offers opportunities for internships, research and professional development through selected programmes. Its campus is located in a relatively small city along the Mississippi River.